Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, study aimed perform the synthesis characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types fluoroquinolones, along Cu2+ or Ag+ species evaluate antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, including clinical multi-drug-resistant strains S. aureus P. aeruginosa. addition, in order obtain an effective material promote wound healing, well-known proliferative agent, phenytoin sodium, was adsorbed onto one silver-functionalized materials. Furthermore, biofilm studies generation reactive oxygen (ROS) were also carried out determine potential synthesized sense, showed activity E. potentially due increased ROS (up 3 times), whereas exhibited broader spectrum activity, even inhibiting MRSA particular, sodium ability reduce development by up 55% inhibit growth “wound-like medium” 89.33%.